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Greendept. dRp 14 [V1S(R Rp)][k1 þ R Rp] [V2Rp][k2 þ Rp] (14:13) dt k1 14 Michaelis constant of phosphorylated enzyme R1 k2 14 Michaelis constant of phosphorylated enzyme R2 V1 14 max rate of phosphorylation V2 14 max rate of loss of phosphorylation S 14 stimulus or signal R 14 amount or concentration of enzyme R in the unphosphorylated form Rp 14 amount or concentration of enzyme R in the phosphorylated form This approach is more realistic because these enzymes follow MichaelisMenten kinetics (Fig.
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