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Figure 6.Phillips, R. ; 14. Guillem Germline Mutation (Inherited Disease) One copy mutated in every cell (first hit is inherited) Second copy mutated in cell (second hit is acquired) Two normal copies of the gene in every cell One copy mutated in cell (first hit is acquired) Second copy mutated in cell (second hit is also acquired) Somatic Mutation (Sporadic Disease) FIGURE 23-5.
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